Molecule.one’s AI chemist, Maria, utilizes GPT-5.4 to enhance Chan-Lam Coupling yields by over 80% with a surprising additive across tested substrates. OpenAI aims to leverage advanced AI to assist scientists in exploring ideas, designing experiments, and accelerating discoveries.

OpenAI has launched GPT-5.4, a foundation model designed for professional and technical tasks, achieving 83% on a pro-level knowledge benchmark. The update features context windows of up to one million tokens and introduces native computer-use capabilities for AI agents, enhancing reasoning, coding, and workflow automation.

GPT-5.4 Thinking and GPT-5.4 Pro are now available in ChatGPT, as well as through the API and Codex. This version integrates advancements in reasoning, coding, and agentic workflows into a single model.

GPT-5.4 Thinking and GPT-5.4 Pro are now rolling out in ChatGPT, along with availability in the API and Codex. The model integrates advancements in reasoning, coding, and agentic workflows.